Researchers (Noor, Shapira, Edri, Gal, Wertheim, and Dvir) at the School for Cell Biology and Biotechnology, Tel Aviv University, Tel Aviv Israel report “3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts”. They report on “the development and application of advanced 3D printing techniques using the personalized hydrogel as a bioink.” Their experiments included two cellular models. “One model was used as a proof‐of‐concept for the patient‐specific treatment and included induced pluripotent stem cells (iPSCs)‐derived cardiomyocytes (CMs) and ECs. The second model relied on rat neonatal CMs, human umbilical vein endothelial cells (HUVECs) and lumen‐supporting fibroblasts, allowing large‐scale printing.”
The team 3D printed highly vascularized and perfusable cardiac patches that completely match all aspects of the immunological, cellular, biochemical bio profile of the patient. They further explain that a biopsy of an omental tissue is taken from patients and their cells are reprogrammed to become pluripotent stem cells and differentiated to various cell types. Those cell types are namely cardiomyocytes and endothelial cells and the extracellular matrix is processed into a personalized hydrogel. More to read in the link provided below.
Photo Credit: Advanced Science. © 2019 The Authors.