Karius’ Blood Test: Non-Invasive Blood Test Based on Next Generation Sequencing

By July 23, 2019Biotechnology

Excerpts by Lawrence Jones, Ph.D.

A new test on the horizon the Karius Test is a “non-invasive blood test based on next-generation sequencing of microbial cell-free DNA.” It can identify and quantify over 1,000 clinically relevant pathogens including bacteria, DNA viruses, fungi, and parasites.” The test uses next-generation sequencing technology to analyze microbial DNA detected in plasma, the liquid part of blood.  A requirement is that the blood should be sterile, so the detection of microbial DNA in plasma indicates infection. Berezow (2019) reports that “the company claims in a paper published in the prestigious journal Nature Microbiology that it can identify approximately 1,250 different human pathogens within 24 hours of receiving the sample.” This test is advantageous since this includes pathogens that are difficult to culture or identify without an invasive medical procedures. Biospace (2019)”Rigorous clinical studies of the Karius Test continue to show its ability to identify and quantify pathogens from a single blood test,” said Karius Co-founder and CEO, Dr. Mickey Kertesz.”


Biospace (Jun 20, 2019). New Data Shows That Karius Blood Test Can Non-Invasively Detect Pathogens in Deep Infections.Biospace.


Berezow, A. (July 10, 2019). Karius’ Blood Test Detects 1,250 Different Microbial Pathogens. American Council on Science and Health. https://www.acsh.org/news/2019/07/10/karius-blood-test-detects-1250-different-microbial-pathogens-14143

Farnaes,L.  (2019).https://www.kariusdx.com/blog

O’Grady, J. (2019). A powerful, non-invasive test to rule out infection. Nature microbiology, 4(4), 554. https://www.nature.com/articles/s41564-019-0424-7

Photo Courtesy:

Johns Hopkins Whiting School of Engineering – Johns Hopkins University

Leave a Reply