The postdoctoral fellow will advance our understanding of solution behavior of antibodies (protein-protein self-association) that leads to protein aggregation and viscosity in highly concentrated biologic drug solutions.
The primary responsibility of the candidate will be to implement modern NMR techniques and further develop high-resolution NMR spectroscopy toolbox to investigate large proteins. Develop structural models using sparse NMR data and molecular modeling and help improve the design and/or selection of monoclonal antibody candidates optimal for clinical development. Work closely in collaboration with bioprocess scientists and high-field NMR instrumentation facilities.
The successful candidate shall be highly motivated, hardworking, and intellectually productive team player. He/she shall be expected to publish in high impact scientific journals and contribute towards Pfizer’s expertise on biopharmaceutical drug development. Fluency in oral and written English is required. Good inter-personal and communication skills are required. Must be a dedicated and independent thinker with strong research and organizational skills
Ph.D. in Biophysics, Biochemistry, Chemical Engineering or related fields required; 1 – 2 years of postdoctoral research experience preferred
* Expertise in modern NMR pulse programs and processing tools with direct experience in large proteins.
* Expertise in structure computation using sparse NMR data (RDC/PCS/PRE) and restrained molecular dynamics tools, and creative scripting experience is desirable.
* Experience in isotopic labeling of proteins (preferably mammalian cells) and protein purification and sample preparation for NMR purpose.
* Advanced understanding of antibody structure-function.
* Experience in probing Protein: Protein interactions in relation to aggregation and viscosity.
* Experience in biophysical characterization of proteins.
* Proven scientific research productivity as demonstrated by publications in high impact journals.