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Postdoctoral Fellow, Antibody Structure and Dynamics, NMR – Pfizer (Cambridge, MA)

By December 18, 2015Jobs

Role Description 
The postdoctoral fellow will advance our understanding of solution behavior of antibodies (protein-protein self-association) that leads to protein aggregation and viscosity in highly concentrated biologic drug solutions.

Responsibilities 
The primary responsibility of the candidate will be to implement modern NMR techniques and further develop high-resolution NMR spectroscopy toolbox to investigate large proteins. Develop structural models using sparse NMR data and molecular modeling and help improve the design and/or selection of monoclonal antibody candidates optimal for clinical development. Work closely in collaboration with bioprocess scientists and high-field NMR instrumentation facilities.

The successful candidate shall be highly motivated, hardworking, and intellectually productive team player. He/she shall be expected to publish in high impact scientific journals and contribute towards Pfizer’s expertise on biopharmaceutical drug development. Fluency in oral and written English is required. Good inter-personal and communication skills are required. Must be a dedicated and independent thinker with strong research and organizational skills

Qualifications 
Ph.D. in Biophysics, Biochemistry, Chemical Engineering or related fields required; 1 – 2 years of postdoctoral research experience preferred

* Expertise in modern NMR pulse programs and processing tools with direct experience in large proteins.

* Expertise in structure computation using sparse NMR data (RDC/PCS/PRE) and restrained molecular dynamics tools, and creative scripting experience is desirable.

* Experience in isotopic labeling of proteins (preferably mammalian cells) and protein purification and sample preparation for NMR purpose.

* Advanced understanding of antibody structure-function.

* Experience in probing Protein: Protein interactions in relation to aggregation and viscosity.

* Experience in biophysical characterization of proteins.

* Proven scientific research productivity as demonstrated by publications in high impact journals.

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